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Panama City, Panama
Start in the vibrant Casco Viejo neighbourhood, a UNESCO-listed old quarter full of colonial architecture and rooftop bars. Don't miss a visit to the iconic Panama Canal at Miraflores Locks. Try ceviche and patacones at the Mercado de Mariscos seafood market.
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Colón, Panama
Head to the Caribbean side to visit the Gatun Locks, the largest of the Panama Canal's lock systems. Explore the lush rainforest of the Soberanía National Park nearby. The area offers excellent birdwatching with hundreds of species including toucans and harpy eagles.
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El Valle de Antón, Panama
This charming mountain town sits inside the crater of an ancient extinct volcano. Visit the Sunday market for local crafts, golden frogs, and fresh produce. Hike to La India Dormida ridge for panoramic views of the crater valley.
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Santa Catalina, Panama
A laid-back surf village on the Pacific coast renowned for some of Central America's best waves. It's also the main gateway for boat trips to the remote Coiba National Park, a UNESCO World Heritage marine reserve. Snorkelling and diving here reveal whale sharks, manta rays, and vibrant coral.
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Bocas del Toro, Panama
This stunning Caribbean archipelago is Panama's most popular beach destination, with colourful stilted houses over turquoise water. Explore Isla Bastimentos for pristine beaches and the Red Frog Beach wildlife reserve. Try fresh lobster at the waterfront restaurants in Bocas Town and kayak through mangrove channels.