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Cartagena, Colombia
Start in Cartagena's magical walled Old City, a UNESCO World Heritage Site. Wander cobblestone streets, enjoy fresh ceviche, and sip cocktails in the lively Getsemaní neighbourhood.
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Medellín, Colombia
Medellín is a vibrant city of eternal spring with a fascinating transformation story. Ride the famous Metrocable for panoramic views and explore the street art of Comuna 13.
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Quito, Ecuador
Quito sits dramatically at 2,850m altitude with one of the best-preserved historic centres in Latin America. Visit the Basílica del Voto Nacional and try a hearty locro de papa soup.
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Lima, Peru
Lima is the culinary capital of South America — don't miss ceviche in the Miraflores district. Explore the ancient Huaca Pucllana pyramid right in the middle of the city.
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Cusco, Peru
The historic capital of the Inca Empire is the gateway to Machu Picchu. Spend a day acclimatizing, exploring the Plaza de Armas and Inca stonework before heading to the Sacred Valley.
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La Paz, Bolivia
La Paz is the world's highest administrative capital, perched at over 3,600m. Take the Mi Teleférico cable car for stunning views and visit the colourful Witches' Market.
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Uyuni, Bolivia
The Salar de Uyuni is the world's largest salt flat and one of South America's most surreal landscapes. Join a 3-day jeep tour to see flamingos, coloured lagoons and volcanic peaks.
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San Pedro de Atacama, Chile
This desert oasis is surrounded by otherworldly landscapes including the Valle de la Luna and El Tatio geysers. The clear skies make it one of the best stargazing spots on Earth.
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Buenos Aires, Argentina
Buenos Aires is a cosmopolitan city with a passionate tango culture and incredible steak. Explore the colourful La Boca neighbourhood, the elegant Recoleta cemetery and late-night parrillas.
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Rio de Janeiro, Brazil
End the journey in Rio, one of the world's most breathtaking cities. Hike to Christ the Redeemer, relax on Ipanema beach, and take the cable car up Sugarloaf Mountain at sunset.