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Cartagena, Colombia
Start your journey in this colorful Caribbean city with its stunning walled old town. Explore the historic Castillo San Felipe, wander the flower-draped streets of Getsemaní, and feast on fresh ceviche and arepas de huevo.
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Medellin, Colombia
The City of Eternal Spring sits in a lush Andean valley with a perfect year-round climate. Ride the famous Metrocable for panoramic views, visit the vibrant El Poblado neighborhood, and sample world-class Colombian coffee.
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Quito, Ecuador
Ecuador's high-altitude capital boasts one of the best-preserved colonial old towns in Latin America, a UNESCO World Heritage Site. Visit the Basilica del Voto Nacional, stand on the equator at Mitad del Mundo, and try locro de papa soup.
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Cusco, Peru
The ancient Inca capital is the gateway to Machu Picchu and the Sacred Valley. Spend a couple of days acclimatizing, explore the impressive Sacsayhuamán ruins above the city, and don't miss a classic pisco sour in the Plaza de Armas.
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Machu Picchu, Peru
One of the world's most iconic archaeological sites, this Inca citadel sits dramatically above the clouds. Take the train from Ollantaytambo or hike the legendary Inca Trail, and arrive early to beat the crowds and morning mist.
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La Paz, Bolivia
The world's highest administrative capital is a thrilling, chaotic city wedged into a dramatic canyon at over 3,600m. Ride the Mi Teleférico cable car system for stunning views, browse the witches' market Mercado de las Brujas, and day-trip to the Valley of the Moon.
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Uyuni Salt Flat, Bolivia
The world's largest salt flat is utterly surreal, especially in December and January when seasonal rains create a perfect mirror reflection of the sky. Join a multi-day jeep tour to see colorful lagoons, flamingos, and steaming geysers in the remote Altiplano.
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Buenos Aires, Argentina
South America's most cosmopolitan city buzzes with culture, food, and late-night energy. Wander the colorful La Boca neighborhood, watch a live tango show in San Telmo, and indulge in a world-class steak at a traditional parrilla.
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El Chalten, Argentina
Argentina's trekking capital sits at the foot of the jagged Fitz Roy massif in Los Glaciares National Park. December and January are the best months to hike here, with long daylight hours perfect for reaching the iconic Laguna de los Tres viewpoint.
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Torres del Paine, Chile
One of the world's greatest national parks, Torres del Paine dazzles with granite towers, turquoise lakes, and roaming guanacos. Hike the famous W Trek or the full O Circuit in peak summer season, and keep an eye out for condors soaring overhead.
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Rio de Janeiro, Brazil
End your journey in one of the world's most beautiful cities, framed by jungle-covered mountains and sweeping beaches. Hike up to Christ the Redeemer, relax on Ipanema Beach, and soak up the electric summer atmosphere of the Cidade Maravilhosa.
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Florianopolis, Brazil
Brazil's island city is famous for its stunning beaches and laid-back surf culture — at its absolute best in January summer heat. Hit the popular Praia da Joaquina for surfing or the calm waters of Lagoa da Conceição for a relaxing finale to your trip.
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Sao Paulo, Brazil
Wrap up your adventure in South America's largest metropolis, a global food capital with an incredible restaurant and arts scene. Explore the vibrant Vila Madalena street art district, visit the Museu do Ipiranga, and fly home from one of its two international airports.